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KMID : 0360220100510020241
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Journal of the Korean Ophthalmological Society
2010 Volume.51 No. 2 p.241 ~ p.247
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Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients
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Lee Na-Young
Ahn Myung-Duk
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Abstract
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Purpose: In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma.
Methods: Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, triglycerides, LDL, HDL, and highsensitivity C-reactive protein (hsCRP). Also, ET-1 and MCP-1 were measured using enzyme-linked immunosorbent assay kits.
Results: The results of the blood examinations showed no statistically significant differences in hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, LDL, HDL, and hsCRP. Only triglycerides showed a statistically significant difference between the groups (P=0.03). The level of serum ET-1 was significantly higher in the normal tension glaucoma group (P=0.007). The results of MCP-1 showed no statistically significant difference.
Conclusions: We conclude that normal tension glaucoma Is associated with an increased level of triglycerides and that the level of ET-1 could be a hemodynamic cause of normal tension glaucoma.
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KEYWORD
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Endothelin-1, Hemodynamic factors, High-sensitivity C-reactive protein, Macrophage chemoattractant protein-1, Normal tension glaucoma
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